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鞎岇笭頃橃澊毹胳潣 旃橂�岇棎 頇滌毄霅犾垬 鞛堧姅 頃奠嫭鞝� 欷勱赴靹疙彫甑� 氚濏榾... 
頇橃瀽 毵烄钉順� 靹疙彫 旃橂�� 氚╈晥 鞝滌嫓
靹戈硠 斓滉碃鞚� 頃欖垹 鞝�雱� Nature 鞛愲Г歆� Nature communication 鞓�霛检澑 韺� 瓴岇灛

鈼� 霃欔淡雽赌顷欔祼 旯�膦呿晞 甑愳垬 鞐瓣惮韺�鞚� 雼�鞚检劯韽� 霠堧波鞚� 鞝勳偓觳� 頂勲�滍寣鞚茧�� 攵勳劃鞚� 韱淀晿鞐� 旃橂Г 頇橃瀽 氚� 氇�雿� 毵堨毎鞀� 雵岇棎 臁挫灛頃橂姅 旃橂Г鞐� 靸堧�滌毚 鞗愳澑鞚� 霅橂姅 頋�靻岆弻旮办晞甑愳劯韽�(Oligodendrocyte)毳� 氚滉铂頃橃榾瓿�, 鞚措ゼ 韸轨澊鞝侅溂搿� 鞝滌柎頃橃棳 旃橂�岉暊 靾� 鞛堧姅 靸堧�滌毚 靹疙彫 旃橂�岇潣 臧�電レ劚鞚� 鞝滌嫓頃橃棳 Nature communication (IF:17.6)歆� 2鞗� 順胳棎 氚滍憸頃橃榾雼� .
  * 頋�靻岆弻旮办晞甑愳劯韽� : 觳欖稊霃欕�检潣 欷戩稊鞁犼步瓿勳棎靹� 雺措煱鞚� 歆�歆�頃橂姅 鞐�頃犾潉 頃橂姅 靹疙彫.

鈼� 鞚措矆 鞐瓣惮鞐愳劀 雼�鞚检劯韽� 鞝勳偓觳� 頂勲�滍寣鞚茧�� 攵勳劃鞚措澕電� 斓滌嫚 鞁滌姢韰� 靸濏檾頃� 旮办垹鞚� 頇滌毄頃橃棳, 旃橂Г 歆堩櫂 韸轨澊鞝侅澑 頋�靻岆弻旮办晞甑愳劯韽�鞕� 頋�靻岆弻旮办晞甑愳劯韽� 鞝勱惮欷勱赴靹疙彫(Oligodendrocyte progenitor cells)毳� 氚滉铂頃橃榾鞙茧┌, 鞚措ゼ 旃橂Г歆堩櫂 韸轨澊 頋�靻岆弻旮办晞甑愳劯韽� (DAO, Disease associated oligodendrocyte)霛� 氇呺獏頃�.
  * 雼�鞚检劯韽� 鞝勳偓觳� 頂勲�滍寣鞚茧�� 攵勳劃 : “1臧�”鞚� 靹疙彫毳� 攵勲Μ頃橃棳, 頃措嫻 靹疙彫鞚� 鞙犾爠觳挫爜 韸轨�曥潉 攵勳劃頃橂姅 斓滌嫚鞚� 靸濍�检爼氤错暀 旮办垹

鈼� 韸鬼瀳 雼�鞚检劯韽� 鞝勳偓觳� 頂勲�滍寣鞚茧�� 攵勳劃鞚� 雼�鞚检劯韽� 雿办澊韯半ゼ 鞐瓣舶甑�臁�(Pseudotime analysis)霛茧姅 攵勳劃鞚� 韱淀晿鞐� 旃橂Г 歆勴枆瓿检爼 韸轨澊鞝侅溂搿� 頋�靻岆弻旮办晞甑愳劯韽� 鞝勱惮欷勱赴靹疙彫(Oligodendrocyte progenitor cell)攵�韯� 靹膘泊 頋�靻岆弻旮办晞甑愳劯韽�旯岇��鞚� 氤�順曤悳 攵勴檾 瓴诫�滊ゼ(developmental lineage)毳� 攴滊獏顷橃榾雼�.

鈼� 霕愴暅 鞚措晫 牍勳爼靸侅爜鞙茧�� 歃濌皜頃橂姅 Erk霛茧姅 鞁犿樃鞝勲嫭瓴诫�滊ゼ 氚濏榾雮挫棃鞙茧┌, 鞚措ゼ 韮�旯冹溂搿滍晿鞐� 臁办爤頃� 靾� 鞛堧姅 鞎诫�检潉 韴�鞐�頃� 瓴瓣臣 旃橂Г 毵堨毎鞀れ潣 頄夒彊鞁ろ棙鞐愳劀 鞝勲皹鞝侅澑 鞚胳��鞝� 電ル牓鞚� 旃橂�� 須�瓿茧ゼ 頇曥澑顷橃榾雼�.

鈼� 韸鬼瀳 旯�膦呿晞 甑愳垬電� 鞁れ牅 旃橂Г 頇橃瀽鞚� 頂检�� 頋�靻岆弻旮办晞甑愳劯韽� 雿办澊韯办檧鞚� 靸侁磤甏�瓿� 攵勳劃鞚� 韱淀暣, 氇�雿� 毵堨毎鞀る繍毵� 鞎勲媹霛� 鞎岇笭頃橃澊毹� 旃橂Г 頇橃瀽鞚� 雵岇棎靹滊弰 鞚挫檧 鞙犾偓頃� 靹疙彫甑办潣 鞐�頃犾潉 攴滊獏顷橃榾雼�.
  

鈼� 鞐瓣惮毳� 雼措嫻頃� 旯�膦呿晞 甑愳垬電� “鞚措矆 鞐瓣惮電� 鞎岇笭頃橃澊毹胳劚 旃橂Г鞐� 雽�頃� 頋�靻岆弻旮办晞甑愳劯韽�毳� 韱淀暅 臧曤牓頃� 旃橂�� 須�瓿茧ゼ 頇曥澑頄堨潉 肟� 鞎勲媹霛�, 韲错枆靹� 雵岇�堩櫂鞐� 氚滊硲鞐� 鞛堨柎靹� 頋�靻岆弻旮办晞甑愳劯韽� 氚� 頋�靻岆弻旮办晞甑愳劯韽� 鞝勱惮欷勱赴靹疙彫鞚� 鞐�頃犼臣 鞛犾灛霠レ潉 靸堧…瓴� 鞝滌嫓頃滊嫟電� 雿� 鞚橃潣”臧� 鞛堧嫟. 霕愴暅 攴茧掣鞝侅澑 旃橂�岇牅臧� 鞐嗠姅 旃橂Г歆堩櫂鞐� 頇滌毄頃� 靾� 鞛堧姅 靸堧�滌毚 欷勱赴靹疙彫旃橂�岇垬雼�鞚� 頇曤炒頃橃棳 鞁れ毄頇� 頃� 靾� 鞛堧姅 瓿勱赴臧� 毵堧牗霅� 瓴冹棎 韥� 鞚橂�戈皜 鞛堨潉 瓴�”霛缄碃 靹る獏頄堧嫟.

鈼� 鞚措矆 鞐瓣惮電� 雽赌顷欖�戩爯鞐瓣惮靻岇偓鞐�, 氩旊秬觳橃灛靸濎潣耄岅赴靾犼皽氚滌偓鞐呺嫧 氚� 靷检劚氙鸽灅旮办垹鞙§劚靷�鞐呾棎靹� 歆�鞗愲皼鞎� 靾橅枆霅橃棃雼�.

鈼� 頃滍幐, 鞚措矆 鞐瓣惮 瓴瓣臣電� 靹戈硠 斓滉碃鞚� 頃欖垹 鞝�雱� Nature 鞛愲Г歆� Nature communication 鞓�霛检澑 韺�(IF=17.9)鞐� 瓴岇灛霅橃棃雼�.

* 雲茧�鸽獏
Single-cell RNA-sequencing identifies disease-associated oligodendrocytes in male APP NL-G-F and 5XFAD mice

* 氤� 鞛愲�岇檧 甏�霠�霅� 氍胳潣電� 霃欔淡雽赌顷欔祼 頇旐暀瓿� 旯�膦呿晞 甑愳垬 (02-2260-3321, jk2316@gmail.com)鞐愱矊 頃挫＜鞁滉赴 氚旊瀺雼堧嫟.