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鞎堩潿觳� 甑愳垬 鞐瓣惮韺� (鞎巾暀瓿�)鞚� 氙戈淡 University of Utah, Jared Rutter 甑愳垬韺�瓿检潣 瓿惦彊鞐瓣惮 瓴瓣臣毳� 韱淀暣 鞐愲剤歆� 雽�靷�鞕� 甏�霠�霅� 須�靻岇檧 雽�靷�觳� 靷�鞚挫潣 靸來樃鞛戩毄鞚� 攵勳劃頃橂姅 氚╇矔鞚� 臧滊皽頃橃榾雼�. 靸濎泊雮� 雽�靷�觳� 雱ろ姼鞗岉伂電� 雼れ枒頃� 靹疙彫 鞛戩毄鞐� 鞓來枼鞚� 氙胳箻氅�, 須�靻�-雽�靷�觳� 靸來樃鞛戩毄鞚� 觳搓硠鞝侅澑 攵勳劃鞚� 毵れ毎 霃勳爠鞝侅澑 瓿检牅鞚措嫟.

瓿惦彊鞐瓣惮韺�鞚� 歆堧焿攵勳劃氩曥棎 旮半皹頃橃棳 觳搓硠鞝侅溂搿� 鞎岆�滌姢韰岆Ν 臁办爤 雽�靷�觳措ゼ 攵勳劃頃橂姅 氚╇矔(MIDAS, Mass spectrometry Integrated with equilibrium Dialysis for the discovery of Allostery Systematically)鞚� 臧滊皽頃橃棳 鞚戈皠鞚� 韮勳垬頇旊�� 雽�靷�鞐� 甏�瓿勲悳 33臧� 須�靻岇棎 雽�頃� 830臧滌潣 須�靻�-雽�靷�觳� 靸來樃鞛戩毄鞚� 氚濏榾雰堧嫟. 鞐�旮办棎電� 鞚措�� 鞎岆牑歆� 臁办爤雽�靷�觳�, 須�靻� 旮办�� 氚� 雽�靷�靷半�缄臣 雿旊秷鞏� 鞁犼窚 雽�靷�觳� 靸來樃鞛戩毄鞚� 韽�頃�霅橃柎 鞛堧嫟.

鞐瓣惮歆勳潃 攵勳劃瓴瓣臣搿滊秬韯� 旮挫偓鞀�旖旍棓鞛愳瀯A鞐� 鞚橅暅 鞙犽嫻韮堨垬靻岉毃靻�(lactate dehydrogenase)鞚� 霃欖�呿毃靻� 鞚错槙 韸轨澊鞝� 鞝�頃� 鞛戩毄鞚� 氚滉铂頃橃棳,靹疙彫 雮挫棎靹� 鞚错槙 鞙犽嫻韮堨垬靻岉毃靻岇潣 氚滍槃鞚� 歆�氚╈偘鞐� 鞚橅暣 臁办爤霅�鞚� 氚濏榾雰堧嫟. 鞚措煬頃� 須�靻�-雽�靷�觳� 靸來樃鞛戩毄 攵勳劃鞚� 臁办�來姽鞚挫爜 雽�靷�觳挫潣 雼れ枒靹膘棎 鞚橅暣 靹疙彫鞚� 靹膘灔瓿� 靸濎〈鞚� 氚�鞝戫晿瓴� 甏�霠�霅橃柎 鞛堨潓鞚� 鞚橂�疙暅雼�. 霕愴暅 鞐瓣惮 瓴瓣臣電� 雽�靷�靹� 歆堩櫂鞚� 響滌爜鞙茧�� 頃橂姅 鞝�攵勳瀽 頇旐暕氍� 鞁犾暯臧滊皽鞐� 頇滌毄霅� 靾� 鞛堧嫟.

鞚� 鞐瓣惮電� 氙戈淡, 頃滉淡, 鞀れ洦雿挫潉 韽�頃�頃� 7臧滉淡 甑�鞝� 瓿惦彊鞐瓣惮鞚� 瓴瓣臣氍检澊氅�,鞖半Μ雽赌顷� 鞎堩潿觳� 甑愳垬電� 毵愳偘韮堨垬靻岉毃靻�(malate dehydrogenase)鞚� 靸濎偘 氚忞寑靷�觳� 攵勳劃鞐� 旮办棳頃橃榾雼�. 鞐瓣惮瓴瓣臣電� 鞓る姅 3鞗� 10鞚� Science鞐� 氚滍憸鞓堨爼鞚措嫟.

攴鸽�检劋氇�. (A) MIDAS 攵勳劃鞐� 鞚橅暣 氚滉荡霅� 須�靻�-雽�靷�觳� 靸來樃鞛戩毄 歆�霃�, 氤� 鞐瓣惮鞐愳劀 攵勳劃霅� 瓴瓣臣臧� 鞝愳溂搿� 響滌嫓霅�, (B) MIDAS 攵勳劃 臧滊厫霃�