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霃欔淡雽�(齑濎灔 鞙れ灛鞗�)電� 霃欔淡雽� 鞎巾暀雽赌顷� 鞚搓步 甑愳垬臧� 靸濏檾頃欕秳鞛愳儩氍柬暀須�(須岇灔 旯�鞓侅��)臧� 靹犾爼頃橁碃 靸濍獏瓿淀暀旮办梾 毵堩伂搿滌牋(雽�響滌澊靷� 旯�彀巾泩)鞚� 頉勳洂頃橂姅 ‘2023雲勲弰 毵堩伂搿滌牋 鞐�靹标臣頃欖瀽靸�’ 靾橃儊鞛愲�� 靹犾爼霅愲嫟瓿� 18鞚� 氚濏様雼�. 鞁滌儊鞁濎潃 歆�雮� 11鞚� 攵�靷� 韺岆澕雼れ澊鞀ろ樃韰旍棎靹� 臧滌禍霅� ‘2023 靸濏檾頃欕秳鞛愳儩氍柬暀須� 甑�鞝滍暀靾犽寑須�’鞐愳劀 歆勴枆霅愲嫟.

霃欔淡雽� 鞚搓步 甑愳垬電� 歆�雮� 20鞐� 雲勱皠 鞚橃暯頇旐暀 旮半皹鞚� 鞁犾暯臧滊皽 欷戧皽鞐瓣惮 攵勳暭鞐愳劀 頇滊皽頃� 鞐瓣惮 頇滊彊鞚� 靾橅枆頃挫檾雼�. Nature Communication, Journal of Medicinal Chemistry, Experimental Molecular Medicine, Angewandte Chemie 霌� 雼れ垬鞚� high impact 鞝�雱愳棎 甑愳嫚鞝�鞛愲�� 雲茧�胳潉 氚滍憸頄堧嫟.

鞚搓步 甑愳垬電� 順侅嫚鞁犾暯 臧滊皽 鞝勲�戈皜搿� 鞎� 氚� 鞐检�� 歆堩櫂鞚� 臁办爤頃橂姅 旮�搿滊矊 靾橃��鞚� 頇旐暕氍� 鞁犾暯 頉勲炒氍检�堨潉 臧滊皽頃橁碃 臧滊癌順� 欷戧皽鞐瓣惮毳� 韱淀暅 靷绊暀鞐� 鞙淀暕鞐瓣惮搿� 鞖办垬頃� 靹标臣毳� 霃勳稖頃� 鞝愳潉 雴掙矊 韽夑皜 氚涭晞 鞚措矆 靸侅潉 靾橃儊頃橁矊 霅愲嫟. 韸鬼瀳 鞎� 韸轨澊鞝� 鞝�靷办唽 氙胳劯頇橁步 (tumor microenvironment)鞐愳劀 頃�鞎旐毃瓿茧ゼ 雮橅儉雮措姅 氍检�� LW6鞚� 韮�瓴熿澊 MDH2 (malate dehydrogenase 2)霛茧姅 瓴冹潉 頇旐暀鞝� 霃勱惮 (chemical probe)毳� 頇滌毄頃橃棳 斓滌磮搿� 攴滊獏頄堦碃, (Angewandte Chemie 2012, J Med Chem 2012, 2014, 2017), 歆�靻嶌爜鞚� 雼ろ暀鞝滉皠 欷戧皽鞐瓣惮毳� 韱淀晿鞐� IDF-774鞕� 臧欖潃 鞛勳儊頉勲炒氍检�� (IND 鞀轨澑, Cell Death & Diesease, 2017) 氚� 靾橃�呾潣 頃�鞎� 鞛勳儊 頉勲炒氍检�� 韺岇澊頂勲澕鞚� 臧滊皽鞐� 旮办棳頃� 氚� 鞛堧嫟.

霕愴暅 霃呾敖鞝侅澑 頃�鞎� 旮办爠 (HIF, HSP70, MDH, IL-6, BLT2, AIMP2-DX2)鞐� 鞛戩毄頃橂姅 頇旐暕氍� 臧滊皽 鞐瓣惮 (LW1497, LW1564, DK1108, BC-DXI-495, BC-DXI-32982 霌�), 鞎诫�检劚 頇旐暕氍� 霛检澊敫岆煬毽� 甑�於� 鞐瓣惮 (Advanced Synthesis & Catalyst 2018, Green Chemistry 2022)搿� 190鞐�韼胳潣 SCI/E 雲茧�胳潉 氚滍憸頄堧嫟. 旮办磮鞐瓣惮鞐愲�� 毹鸽�检�� 鞎婈碃 鞛勳儊 氚� 鞝滌暯鞐呹硠鞚� unmet need毳� 氚橃榿頃� 鞏戨癌頄� 欷戧皽鞐瓣惮毳� 韱淀暣 鞖办垬 韸鬼棃霌れ潉 霃勳稖頃橁碃 10瓯挫潣 靹标车鞝侅澑 旮办垹鞚挫爠 氚� 靷绊暀順戨牓靷�搿�毳� 欤茧弰頄堧嫟.

韸鬼瀳, 3P 鞝勲灥 (Paper, Patent, Product)鞙茧�滌劀 鞖办垬頃� 旮办磮鞐瓣惮臧� 靷�鞛ル悩歆� 鞎婈碃 靸侅毄頇� 臧�電ロ暅 雼�瓿勱箤歆� 臧滊皽霅� 靾� 鞛堧弰搿� 頃勳殧頃� 攵�攵勳潉 鞐瓣舶頃橂姅 臧滊癌順� 順侅嫚(open innovation) 臧滊厫鞚� 欷戧皽鞐瓣惮 韱淀暣 鞝�攵勳瀽 頇旐暕氍� 旮半皹鞚� 鞁犼窚 韺岇澊頂勲澕鞚胳潉 歆�靻嶌爜鞙茧�� 瓿店笁頄堧嫟. 旮办磮·鞗愳矞旮办垹搿� 旮办梾鞚� 靹膘灔 頃滉硠毳� 霃岉寣頃� 順戩梾鞚� 旮胳潉 彀眷晞 旮办磮·鞗愳矞 鞐瓣惮 靹标臣鞚� 旮办垹靷�鞐呿檾 (Lab to Market)鞐愲弰 旮办棳頄堧嫟.

頃滍幐, 鞓�頃措�� 19須岆ゼ 毵烄澊頃� 毵堩伂搿滌牋 鞐�靹标臣頃欖瀽靸侅潃 靸濍獏瓿淀暀攵勳暭鞐愳劀 鞖办垬頃� 鞐�靹� 瓿柬暀鞛愲ゼ 氚滉荡 氚� 歆�鞗愴晿旮� 鞙勴暣 2005雲� 鞝滌爼霅愲嫟. 靸濏檾頃欕秳鞛愳儩氍柬暀須岅皜 靾橃儊鞛愲ゼ 靹犾爼頃橁碃 毵堩伂搿滌牋鞚� 頉勳洂頃橃棳 靸來尐鞕� 頃�昊� 靸侁笀鞚� 靾橃棳頃橁碃 鞛堧嫟.