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(鞕检�诫秬韯�) 霃欔淡雽� 旯�靹膘�� 氚曥偓瓿检爼 頃欖儩 (鞝�1鞝�鞛�), 霃欔淡雽� 旯�甑愲矓 甑愳垬 (甑愳嫚鞝�鞛�)

霃欔淡雽�(齑濎灔 鞙れ灛鞗�)電� 霃欔淡雽� 瓿店臣雽赌顷� 頇旉车靸濍�缄车頃欔臣 旯�甑愲矓 甑愳垬 鞐瓣惮韺�瓿� 鞐办劯雽� 鞝曧暅靹� 甑愳垬 鞐瓣惮韺�鞚� 瓿惦彊鞐瓣惮毳� 韱淀暣 歆�歆堦赴氚橃潣 靸濎泊鞛�耄岆ゼ 頇滌毄, 響滊┐臧滌�� 鞛愳棸靷错暣靹疙彫(Natural killer cell, NK cell)毳� 臧滊皽頃橁碃 鞚措ゼ 韱淀暣 瓿犿槙鞎旍棎 雽�頃� 氅挫棴 頃�鞎旍箻耄岇棎 鞚戩毄頃橂姅 雿� 靹标车頄堧嫟瓿� 氚濏様雼�.

氅挫棴鞖旊矔鞚� 順勳灛 鞐�霟� 膦呺�橃潣 鞎� 旃橂�岇棎靹� 臧�鞛� 靹标车鞝侅澊瓿� 順侅嫚鞝侅澑 氚╇矔鞚� 頃橂倶搿� 攵�臧侂悩瓿� 鞛堧嫟. 攴胳�戩棎靹滊弰 韸鬼瀳 NK靹疙彫電� T 靹疙彫鞚� 頃滉硠毳� 攴闺车頃橂┌ 膦呾枒 靹疙彫毳� 韸轨澊頃橁矊 鞁濍硠頃橁碃 鞝滉卑頃橂姅 霃呿姽頃� 電ル牓鞚� 歆�雼堦碃 鞛堨柎 T 靹疙彫鞚� 雽�鞎堨溂搿� 欤茧�╇皼鞎� 頃�鞎旍箻耄岇潣 靹犽磯鞐� 靹滉碃 鞛堧嫟. 順勳灛 韨る�旊澕 頃�鞗� 靾橃毄觳� (CAR) 鞙犾爠鞛� 霃勳瀰鞚� 韱淀暣 鞝滌瀾霅橂姅 旮半姤靹� 臧曧檾 響滊┐臧滌�� CAR-T 靹疙彫 氚� CAR-NK靹疙彫 旃橂�岇牅電� 順勳灛 頃�鞎旍箻耄岆ゼ 鞙勴暣 頇橃瀽鞐愱矊 韴�鞐�霅橁碃 鞛堦赴霃� 頃橂嫟.

CAR-NK 靹疙彫鞐� 雽�頃� 甏�鞁�瓿� 靾橃殧臧� 雴掛晞歆�氅挫劀 CAR 旮半皹 鞙犾爠瓿淀暀瓿� 甏�霠�霅� 瓿检牅霃� 歃濌皜頃橁碃 鞛堧嫟. 鞙犾爠鞛� 臁办瀾 CAR 靹疙彫鞚� 鞝滌“ 瓿检爼鞚� 順曥�堦皭鞐� 須�鞙�鞚� 雮�瓿�, 霃岇棸氤�鞚� 氚滌儩鞙茧�� 鞚疙暣 靸濎劚霅� NK靹疙彫鞚� 氤胳�堨爜鞚� 靸濍�柬暀鞝� 頇滌劚鞚� 鞝�頃橂悹 靾� 鞛堧姅 霃勳爠鞚� 臁挫灛頃滊嫟.

鞚挫棎 鞐瓣惮韺�鞚� 鞙犾爠鞛� 臁办瀾 鞐嗢澊 NK靹疙彫 響滊┐鞐� 鞎旍劯韽� 鞚胳嫕鞖� 毽�臧勲摐毳� 鞝滌嫓頃� 靾� 鞛堧姅 氚╇矔鞚� 瓿犾晥頄堧嫟. 歆�歆� 旮半皹鞚� 靸濎泊靻岇灛電� 靹疙彫毵夓棎 靻岇垬靹� 靸來樃鞛戩毄鞚� 韱淀暣 攵�彀╇悹 靾� 鞛堧嫟. 鞐瓣惮韺�鞚� 鞎旍劯韽� 響滊┐鞐� 瓿茧皽順勲悩鞏挫瀳電� CD44 靾橃毄觳挫棎 韸轨澊鞝侅溂搿� 瓴绊暕頃橂姅 靸濎泊瓿犽秳鞛愳澑 頌堨晫耄�搿犾偘鞐� 歆�歆堨潉 瓴绊暕頃� 靻岇灛毳� 臧滊皽頃橃棳 NK靹疙彫 響滊┐臧滌�堨棎 鞝侅毄頃橃榾雼�. 攴� 瓴瓣臣 臧滊皽霅� 靻岇灛電� 30攵� 毵岇棎 NK靹疙彫 響滊┐鞚� 靹标车鞝侅溂搿� 臧滌�堩晿鞓�鞙茧┌, 響滊┐臧滌�� NK靹疙彫-鞎旍劯韽� 臧� 氅挫棴 鞁滊儏鞀るゼ 順曥劚頃橃榾雼�. 鞐瓣惮鞐愳劀 臧滊皽霅� 響滊┐臧滌�� NK靹疙彫電� 旆岇灔鞎旍棎 雽�頃� 鞚茧皹 NK靹疙彫 雽�牍� 98%, 頇旐暀 頃�鞎旍牅鞚� Gemcitabine 雽�牍� 88% 頄レ儊霅� 鞝勳瀯靸� 膦呾枒 鞏奠牅 旮半姤靹膘潉 氤挫榾雼�. 霕愴暅 響滊┐臧滌�� NK靹疙彫電� 旆岇灔鞎旍潣 韽� 鞝勳澊 氚� 膦呾枒鞐� 鞚橅暅 鞁犾儩順堦磤 順曥劚鞚� 靹标车鞝侅溂搿� 鞏奠牅頃橂姅 瓴瓣臣毳� 氤挫榾雼�.

霃欔淡雽� 旯�甑愲矓 甑愳垬鞕� 氚曥偓瓿检爼 旯�靹膘�� 頃欖儩鞚� 靸濎泊鞛�耄� 旮半皹 NK靹疙彫 響滊┐臧滌�堨棎 雽�頃� 鞐瓣惮毳� 韱淀暣 靹戈硠 斓滉碃靾橃��鞚� 甑�鞝滍暀靾犾�� Chemical Engineering Journal (IF 15.1), Nano convergence (IF 11.7) 霌膘棎 甑愳嫚鞝�鞛� 氚� 鞝�1鞝�鞛愲�� 雲茧�胳潉 瓴岇灛, 頃欔硠鞚� 欤茧�╈潉 氚涥碃 鞛堧嫟. 旯�甑愲矓 甑愳垬電� "鞚� 旮办垹鞚� 旮办〈鞚� 鞙犾爠鞛� 臁办瀾 旮办垹鞚� 頃勳殧搿� 頃橂姅 3欤� 鞚挫儊 鞝滌“ 瓿奠爼 氚� 瓿犽倻鞚措弰鞚� 旮办垹瓿� 靹る箘 鞐嗢澊 雼�靾滍暅 順柬暕毵岇溂搿� 30攵� 毵岇棎 氅挫棴靹疙彫鞚� 響滊┐鞚� 須�瓿检爜鞙茧�� 氤�順曧暊 靾� 鞛堧嫟“氅� ”鞚措煬頃� 順侅嫚鞝侅澑 旮办垹鞚� 頇橃瀽鞐愱矊 攵�雼措悩電� 旃橂�� 牍勳毄鞚� 雮�於旉碃 旃橂�� 瓿检爼鞚� 臧勳唽頇旐晿電� 雿� 旮办棳頃� 瓴冹溂搿� 鞓堨儊霅橂┌, 氅挫棴頃�鞎� 旃橂�� 攵勳暭鞐愳劀 靸堧�滌毚 歆�韽夓潉 鞐� 靾� 鞛堨潉 瓴冹溂搿� 旮半寑霅滊嫟“瓿� 毵愴枅雼�.

頃措嫻 鞐瓣惮電� 頃滉淡鞐瓣惮鞛�雼�鞚� 旮办磮鞐瓣惮鞁れ��鞗愳偓鞐呹臣 欷戧铂鞐瓣惮鞛愳��鞗愳偓鞐呾潣 歆�鞗愳溂搿� 靾橅枆霅愲嫟. 霕愴暅 ”Surface Engineering of Natural Killer Cells with CD44-targeting Ligands for Augmented Cancer Immunotherapy“ 鞝滊�╈溂搿� 鞛�耄� 攵勳暭 鞝�氇� 甑�鞝滍暀靾犾�� Small (IF 13.2)鞐� 瓴岇灛霅愳溂氅�, BRIC ‘頃滉淡鞚� 牍涬偞電� 靷�霝岆摛’鞐愲弰 靹犾爼霅愲嫟.